mittx (Alomone Labs)

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Alomone Labs mittx
Mittx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mittx/MitTx+Toxin/pm41956146-65-12-16
Average 94 stars, based on 7 article reviews

mittx - by Bioz Stars, 2026-10

94/100 stars

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Glycoproteomics:

Article Title: Redistribution of ASIC1a channels triggered by IL-6: Potential role of ASIC1a in neuroinflammation.
Article Snippet: Cytokines, particularly IL-6, play a crucial role in modulating immune responses in the central nervous system (CNS).. Elevated IL-6 levels have been observed in neuroinflammatory conditions, as well as in the sera and brains of patients with neurodegenerative diseases such as Parkinson’s, Huntington’s, Multiple Sclerosis, and Alzheimer’s.. Additionally, alterations in regional brain pH have been noted in these conditions.

Incubation:

Concentration Assay:

Article Title: Upregulation of ASIC1a channels in an in vitro model of Fabry disease.
Article Snippet: Neuropathic pain is one of the key features of the classical phenotype of Fabry disease (FD).. Acid sensing ion channels (ASICs) are H-gated cation channels, which belong to the epithelial sodium channel/DeGenerin superfamily, sensitive to the diuretic drug Amiloride.. Molecular cloning has identified several distinct ASIC subunits.

Article Title: Signaling Pathways in Proton and Non-proton ASIC1a Activation
Article Snippet: Incubation of cells: ASIC inhibitors were used at the following concentrations before incubation with other reagents: Pctx-1 (Alomone, STP-200), 20 nM, 30 min before; as previously used in Salinas et al. ( ). .. MitTx (Alomone, M-100) was used at a concentration of 20 nM for 2, 10 min according to Alomone Labs and (Bohlen et al., ). ..

Migration:

Article Title: Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and K Ca 3.1 ion channels, but involves phosphoinositide 3-kinase
Article Snippet: .. The effect of ASICs on migration was tested using PcTx1 (Smartox Biotech, Saint-Egrevè, France), APETx2 (Alomone Labs, Jerusalem, Israel), or MitTx (Smartox Biotech) and the effect of KCNN4 and PI3K by TRAM-34 (Selleck Chemicals, Houston, USA) and wortmannin (Selleck Chemicals), respectively. ..

Article Title: Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and K Ca 3.1 ion channels, but involves phosphoinositide 3-kinase.
Article Snippet: .. The effect of ASICs on migration was tested using PcTx1 (Smartox Biotech, Saint-Egrevè, France), APETx2 (Alomone Labs, Jerusalem, Israel), or MitTx (Smartox Biotech) and the effect of KCNN4 and PI3K by TRAM-34 (Selleck Chemicals, Houston, USA) and wortmannin (Selleck Chemicals), respectively. ..

Produced:

Article Title: The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1b.
Article Snippet: .. PcTx1 was produced as previously described (Saez et al., 2011, 2017), and MitTx was purchased from Alomone labs (Cat. No. M-100; Jerusalem, Israel). ..

Purification:

Article Title: Structure and analysis of nanobody binding to the human ASIC1a ion channel
Article Snippet: .. PcTx1 was used at 10 nM and MitTx at 50 nM, both were purchased from Alomone Labs. Oocytes were pre-incubated with purified Nb or Nb-linker-PcTx1 (10 nM) for 20 min at RT before recording. ..

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